July 23, 2019

Systems-based Approach to Biodefense Policy Analysis

In this article, co-authored by Dr. Diane DiEuliis, the authors describe a systems-based analysis of the US biosecurity and biodefense policy landscape to analyze functional relationships between policies. They identify 2 approaches in US policy for countering biological threats: prevention of theft, diversion, or deliberate malicious use of biological technologies, and development of capabilities and knowledge to assess, detect, monitor, respond to, and attribute biological threats.

Dec. 3, 2018

Biotechnology for the Battlefield: In Need of a Strategy

In her article, published on War on the Rocks, CSWMD Senior Research Fellow Dr. Diane DiEuliis discusses the need for a more cohesive strategy to harness the potential uses of biotechnology on the battlefield.

April 4, 2018

Biodata Risks and Synthetic Biology: A Critical Juncture

Intrinsic to growing ability to apply classical engineering to biological systems is the mounting ‘digitization of biology’, as the genetic code and its related metadata (including translated proteins, associated functions, herein referred to as “biodata”) are amassed in order to engineer biology for specific purposes. There are three unique risks categories associated with the digitization of biology: 1) pathogen risks; 2) manufacturing risks, and 3) risks to individual privacy that can allow human harms.

Nov. 3, 2017

Biosecurity Implications for the Synthesis of Horsepox, an Orthopoxvirus

This article examines the biosecurity and biodefense implications resulting from the recent creation of horsepox virus, a noncirculating (extinct) species of orthopoxvirus. Here we examine the technical aspects of the horsepox virus synthesis and conclude that orthopox synthesis experiments currently remain technically challenging—and will continue to be so, even once this work is published in the scientific literature.

Oct. 3, 2017

Options for Synthetic DNA Order Screening, Revisited

DNA synthesis is a valuable research tool in the design of new biological products for medicine and manufacturing, and the ability to chemically synthesize long tracts of DNA has allowed for the development of influenza vaccines and diagnostic tests.

April 14, 2017

The Department of Defense Chemical and Biological Defense Program: An Enabler of the Third Offset Strategy

In the current era of rapidly emerging technologies, adversaries are not only rediscovering chemical and biological weapons; they are also displaying an increased propensity to employ them to cause strategic instability among deployed forces or nations undergoing conflict. The United States's investments in its Chemical and Biological Defense Program (CBDP) can be a critical enabler of the third offset strategy, which is a DOD initiative that seeks to maximize force capability to offset emerging threats.

Nov. 3, 2015

In Good Health? The Biological Weapons Convention and the “Medicalization” of Security

Since the 1990s, the group of stakeholders working to combat biological weapons (BW) proliferation has broadened to include new actors who have not traditionally focused on security issues, including organizations from the public health sector, researchers in the life sciences, and the biosafety community. This has had significant benefits for the

July 1, 2015

The History of Biological Weapons Use: What We Know and What We Don’t

This article critically reviews the literature on the history of biological warfare, bioterrorism, and biocrimes. The first serious effort to review this entire history, made in 1969, had numerous limitations. In recent decades, several authors have filled many of the gaps in our understanding of the past use of biological agents (including both

Oct. 1, 2009

President Nixon’s Decision to Renounce the U.S. Offensive Biological Weapons Program

The nuclear arms race between the United States and the Soviet Union was a prominent feature of the Cold War. A lesser known but equally dangerous element of the superpower competition involved biological weapons (BW), living microorganisms that cause fatal or incapacitating diseases in humans, animals, or plants. By the late 1960s, the United

June 1, 2009

Are We Prepared? Four WMD Crises That Could Transform U.S. Security

This report, written by the staff of the National Defense University Center for the Study of Weapons of Mass Destruction in the fall of 2008 and the early winter of 2009, was conceived initially as a transition paper for the new administration following the 2008 American Presidential election. This report presents four weapons of mass destruction