July 8, 2024

Bolstering Biosecurity Amid the Biotechnology Revolution

The rapid pace of novel technological change, referred to as “emerging technologies,” is challenging our ability to devise policy and governance apace. This is particularly true in the life sciences and biotechnology, where the current tools used for promoting biosecurity via policy and governance are becoming outdated.

Aug. 18, 2023

2023 Biodefense Posture Review

The Biodefense Posture Review was a whole of DOD effort to develop guidance to achieve National Defense Strategy priorities and address biological threats - especially those with strategic consequences for the U.S. military.

Feb. 16, 2023

China's Theater-Range, Dual-Capable Delivery Systems: Integrated Deterrence and Risk Reduction Approaches to Counter a Growing Threat

China has engaged in a dramatic buildup of its nuclear forces over the past decade. While much of the attention on China’s new nuclear arsenal has focused on its development and expansion of its strategic nuclear triad, this growth has also included significant numbers of theater-range, dual-capable delivery systems. These forces are not capable of reaching the U.S. mainland but can range U.S. and allied forces and bases across strategically significant swathes of the Indo-Pacific.

Aug. 18, 2021

Taking Stock of the National Stockpile: Modernizing for a Dynamic Response

Many have acknowledged that the COVID19 pandemic was not a failure of our imagination – we’ve been preparing for such an event for decades by building biotechnologies for biosurveillance and medicines, conducting exercises, and stockpiling of medical supplies – furthermore, response to a spreading illness in many ways is not rocket science: treat the sick, protect the vulnerable, and stop the spread – mainly accomplished via the tools and products of biotechnology. Many are now asking, what could we have done better in the pandemic response?

July 28, 2021

“Designer Biology” and the Need for Biosecurity-by-Design

CSWMD's Dr. Diane DiEuliis and Dr. James Giordano, Departments of Neurology and Biochemistry and Cyber-SMART Center, Georgetown University are featured in the latest issue of CBRNe Society's NCT Magazine.

June 7, 2021

The Origin of Covid-19 and Preventing The Next Pandemic

In a recent article in War on the Rocks, Ms. Amanda Moodie and Dr. Nicholas Evans explore how U.S. policy priorities should focus on both identifying and preventing the spread of zoonotic pathogens and bolstering safety and security in high-containment laboratories.

March 11, 2021

Want to Grow the Economy? Try Fermenting It Instead

U.S. industry’s distribution system and supply chains were vulnerable before COVID, but pandemic-related disruptions to supply chains fully exposed this already alarming problem. U.S. manufacturers have relied too heavily on foreign materials for production, and the steady off-shoring of critical industries over a course of decades has reduced direct control of vital defense-related manufacturing should it be needed.

Feb. 12, 2021

Biodefense and the return to great-power competition

Dr. Gerald Epstein's latest article in The Nonproliferation Review explores the increased likelihood of the development and potential use of biological weapons by Russia and China. This paper is part of a special issue on chemical and biological warfare that is being published in memory of Raymond A. Zilinskas.

Feb. 1, 2021

The Future of Weapons of Mass Destruction: An Update

In an update to their 2014 paper on the future of weapons of mass destruction (WMD), John P. Caves, Jr., and W. Seth Carus assess and offer policy considerations on the significant geopolitical and technological developments shaping the future of WMD since 2014.

Dec. 9, 2020

The biosecurity benefits of genetic engineering attribution

In a recent volume of Nature Communications, Dr. Gerald Epstein and colleagues examine the biosecurity benefits of genetic engineering attribution. This paper is a policy companion piece to a technical paper, published in the same issue, announcing new results in using machine learning to recognize the source of a genetically engineered DNA.

Nov. 10, 2020

Security Implications of Emerging Biotechnologies

June 2016 — On April 26th, 2016, the Center for the Study of Weapons of Mass Destruction (CSWMD) at National Defense University held a workshop to explore “Security Implications of Emerging Biotechnologies.” Participants from government, NGOs and academia discussed opportunities and challenges of a new era of biotechnology.

June 24, 2020

The Health-Security Nexus: Reassessing Priorities after COVID-19

While Covid-19 has spurred debate about the need to elevate public health as a security concern, the securitisation of health presents both opportunities and trade-offs that need to be considered if we are to reallocate military spending to prepare for the next pandemic. Mr. Nima Gerami and Ms. Amanda Moodie address these issues in their latest for The Oxford University Politics Blog.

May 7, 2020

Embrace Experimentation in Biosecurity Governance

Dr. Gerald Epstein and colleagues examine the need to rethink biosecurity governance to address changing technical, social, and political environments.

May 7, 2020

Governing a Pandemic

In their article in Inkstick, Ms. Sarah Jacobs Gamberini and Ms. Amanda Moodie examine China's authoritarian approach to COVID-19 in the context of great power competition.

April 27, 2020

Beyond 1918: Bringing Pandemic Response into the Present, and Future

April 27, 2020 — The current pandemic gives us an opportunity to envision new tools, methods, and response policies that leverage emerging technologies, which, if adopted and prudently employed, would enable capability to far better predict, prepare, if not prevent the “next” biosecurity war, and not merely repeat the errors of the “last”. 

April 13, 2020

Ready or Not: Regaining Military Readiness during COVID19

In the latest Institute for National Strategic Studies "Strategic Insight," Dr. Diane DiEuliis and Dr. Laura Junor examine what the Department of Defense needs to maintain force readiness during the coronavirus (COVID-19) pandemic. Force readiness and management will be improved by rapidly deploying a point of care serological test to all in the U.S. military.

April 6, 2020

The Virus Of Disinformation: Echoes Of Past Bioweapons Accusations In Today’s Covid-19 Conspiracy Theories

In their latest for War on the Rocks, Ms. Sarah Jacobs Gamberini and Ms. Amanda Moodie examine the similarities between current Covid-19 related disinformation campaigns and biological influence operations conducted during the Cold War.

April 2, 2020

Modernizing biotechnology for the fight against COVID-19 and the future of pandemic response

Alexander Titus, Michelle Rozo, and Diane DiEuliis provide some perspective on the importance of using advanced biotechnology capabilities during the global pandemic.

March 25, 2020

Infodemic

In their article in Inkstick, Dr. Justin Anderson and Ms. Sarah Jacobs Gamberini examine the daunting challenge of attempting to halt the spread of misinformation (erroneous information) and disinformation (deliberately false information) about the coronavirus (COVID-19).

Aug. 22, 2019

Biospecimens and the Information Landscape for Biodefense

As genomic sequencing and synthesis tools continue to grow, the genomic information associated with biospecimens is expanding rapidly; the convergence of the physical and digital worlds has yet unexamined impacts to our traditional biodefense frameworks.

July 23, 2019

Systems-based Approach to Biodefense Policy Analysis

In this article, co-authored by Dr. Diane DiEuliis, the authors describe a systems-based analysis of the US biosecurity and biodefense policy landscape to analyze functional relationships between policies. They identify 2 approaches in US policy for countering biological threats: prevention of theft, diversion, or deliberate malicious use of biological technologies, and development of capabilities and knowledge to assess, detect, monitor, respond to, and attribute biological threats.

Dec. 3, 2018

Biotechnology for the Battlefield: In Need of a Strategy

In her article, published on War on the Rocks, CSWMD Senior Research Fellow Dr. Diane DiEuliis discusses the need for a more cohesive strategy to harness the potential uses of biotechnology on the battlefield.

April 4, 2018

Biodata Risks and Synthetic Biology: A Critical Juncture

Intrinsic to growing ability to apply classical engineering to biological systems is the mounting ‘digitization of biology’, as the genetic code and its related metadata (including translated proteins, associated functions, herein referred to as “biodata”) are amassed in order to engineer biology for specific purposes. There are three unique risks categories associated with the digitization of biology: 1) pathogen risks; 2) manufacturing risks, and 3) risks to individual privacy that can allow human harms.

Nov. 3, 2017

Biosecurity Implications for the Synthesis of Horsepox, an Orthopoxvirus

This article examines the biosecurity and biodefense implications resulting from the recent creation of horsepox virus, a noncirculating (extinct) species of orthopoxvirus. Here we examine the technical aspects of the horsepox virus synthesis and conclude that orthopox synthesis experiments currently remain technically challenging—and will continue to be so, even once this work is published in the scientific literature.

Oct. 3, 2017

Options for Synthetic DNA Order Screening, Revisited

DNA synthesis is a valuable research tool in the design of new biological products for medicine and manufacturing, and the ability to chemically synthesize long tracts of DNA has allowed for the development of influenza vaccines and diagnostic tests.

April 14, 2017

The Department of Defense Chemical and Biological Defense Program: An Enabler of the Third Offset Strategy

In the current era of rapidly emerging technologies, adversaries are not only rediscovering chemical and biological weapons; they are also displaying an increased propensity to employ them to cause strategic instability among deployed forces or nations undergoing conflict. The United States's investments in its Chemical and Biological Defense Program (CBDP) can be a critical enabler of the third offset strategy, which is a DOD initiative that seeks to maximize force capability to offset emerging threats.

Nov. 3, 2015

In Good Health? The Biological Weapons Convention and the “Medicalization” of Security

Since the 1990s, the group of stakeholders working to combat biological weapons (BW) proliferation has broadened to include new actors who have not traditionally focused on security issues, including organizations from the public health sector, researchers in the life sciences, and the biosafety community. This has had significant benefits for the

July 1, 2015

The History of Biological Weapons Use: What We Know and What We Don’t

This article critically reviews the literature on the history of biological warfare, bioterrorism, and biocrimes. The first serious effort to review this entire history, made in 1969, had numerous limitations. In recent decades, several authors have filled many of the gaps in our understanding of the past use of biological agents (including both

Oct. 1, 2009

President Nixon’s Decision to Renounce the U.S. Offensive Biological Weapons Program

The nuclear arms race between the United States and the Soviet Union was a prominent feature of the Cold War. A lesser known but equally dangerous element of the superpower competition involved biological weapons (BW), living microorganisms that cause fatal or incapacitating diseases in humans, animals, or plants. By the late 1960s, the United

June 1, 2009

Are We Prepared? Four WMD Crises That Could Transform U.S. Security

This report, written by the staff of the National Defense University Center for the Study of Weapons of Mass Destruction in the fall of 2008 and the early winter of 2009, was conceived initially as a transition paper for the new administration following the 2008 American Presidential election. This report presents four weapons of mass destruction

April 1, 2003

Toward a National Biodefense Strategy

The United States is re-learning an important lesson in the first decade of the 21st century: adversaries may attack the United States, its interests, or those of friends and allies with biological weapons (BW). The last century witnessed the purported use of glanders by the Germans in World War I and the use of dysentery, plague, and typhus by the

Nov. 1, 2002

Anthrax in America: A Chronology and Analysis of the Fall 2001 Anthrax Attacks

This paper describes the 2001 anthrax attacks on the United States and provides a one-year snapshot of the attacks and subsequent response.

Dec. 1, 2001

Adversary Use of NBC Weapons: A Neglected Challenge

This article describes how thinking regarding how an adversary might use nuclear, radiological, biological, or chemical weapons against the United States changed in the last decade of the 20th century.

Feb. 1, 2001

Bioterrorism and Biocrimes: the Illicit Use of Biological Arms in the 20th century

This working paper is an updated study of research that began in 1998; it provides a descriptive analysis of the illicit use of biological agents by criminals and terrorists in the 20th century and draws on a series of specific case studies.

Dec. 1, 1999

DOD and Consequence Management: Mitigating the Effects of Chemical and Biological Attack

This article aims to analyze the potential threat of chemical and biological weapons to the U.S. It also offers recommendations on how to approach these situations and respond appropriately.